Endocrine Abstracts

Introduction: In women, androgens are produced by adrenal glands and ovaries. In peripheral tissues, they result from a conversion of present androgens in the blood circulation. Androgens measurement are of interest in the exploration of hirsutism.Materiel and methods: Retrospective study was conducted over 12 months from January, 2016 to December 2017 in Biochemistry Laboratory of Habib Bourguiba Hospital. Testosterone and prolactin assay were performed...

Introduction: Melatonin is involved in many physiological processes, including the regulation of circadian rhythms, sleep, antioxidant effect, aging, tumor growth, reproduction and bone formation. The latter function is also regulated by the metabolism of vitamin D. Our goal during this study is to detect a possible increase in vitamin D levels under the effect of exogenous melatonin.Participants and methods: Different anthropometric parameters were coll...

Background: Acid Sphingomyelinase Deficiency (ASMD) is a rare lysosomal storage disease caused by mutations in the SMPD1 gene. Typically, the p.Arg610del homozygotes had normal linear growth.Case report: We reported the cases of 2 Tunisian brothers aged 23 and 13 years respectively, who have been admitted for splenomegaly and polyadenopathies. Physical examination showed pubertal and growth delay for both cases. Biological evaluation showed mode...

The aim of the present study was to evaluate the potential toxicity of Cefuroxime (CFR), a second-generation cephalosporin antibiotic, on ovary of ‘wistar’ rats. A total of 32 adult female rats (12 weeks old) were intraperitoneally injected with CFR at a dose of 0, 30, 60 or 120 mg/kg, divided into two equal doses daily, for 7 days and sacrificed 24 h after the last dose. Biochemical assays showed significant reduction in oestradiol and progesterone levels in compari...

Kalach 360 SL (KL), glyphosate (G) surfactant-based herbicides, is a systemic herbicide effective against weeds. It was applied in agriculture in Tunisia and throughout the world, which can represent a risk to non-target organisms. The aim of this study was to investigate the morphological and biochemical aspects of ovary injury after exposure to KL. Female Wistar rats were divided into three groups: group 1 was used as a control; group 2 orally received 0.07 ml of KL, (126 mg...

The present study aimed to investigate the effect of time-of-days (TOD) on some biochemical and hormonal responses after resistance training sessions.Methods: Ten trained subjects performed three resistance-training-sessions at 0700 h, 1300 h and 1700 h. Each training-session included six upper and lower body resistance exercises with 3×10 repetitions. Blood lactate (Lac), creatine kinase (CK), lactate dehydrogenase (LDH), cortisol (C) and testoster...

Imipenem (IMP) is a carbapenem antibiotic mainly used to treat nosocomial infection diseases. We aimed to evaluate the oxidative stress of therapeutic doses of imipenem (IMP) on the ovary of ‘wistar’ rats. In this respect, female rats were divided into four groups: animals were intraperitoneally treated with physiological serum, 30, 50 and 80 mg/kg of IMP for one week. We found that therapeutic doses of this drug did not significantly affect the levels of ovarian mal...

IntroductionThe thresholds of late night salivary cortisol (LNSC) vary widely among studies due to differences in assay methodologies and in control groups. We aimed to verify the analytical performance of the LNSC by electrochimiluminescence assay (ECLIA) and to establish cut-off values of LNSC for the screening of Cushing’s syndrome (CS).MethodsPatients with suspected CS underwent screening tests inclu...

Introduction: Hypothalamic-pituitary-adrenal axis dysfunction (HPA) has been reported in patients with schizophrenia and bipolar disorders but findings are inconsistent and few studies have conducted direct comparaisons of HPA biomarkers in drug native patients. We aimed to assess serum and salivary cortisol in the morning in drug-naive schizophrenic patients compared to controls.Methods: This was a cross-sectional case-control study conducted between Ju...

Introduction: The quality of assay methods for HbA1c assessment has importantly improved last decades, however analytical interferences due to variants of hemoglobin remain of matter vigilance. Immunological interferences, although no longer described, may also occur.Observation: A 84-years-old woman without significant medical history was explored for polyneuropathy. Additional investigation as HbA1c was requested. As no value of HbA1c was obtained when...